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Abnormality of secretion of gastrin
Abnormality of secretion of gastrin
by Alike Medical Team ∙ Updated on June 13, 2023
Additional names
This group contains additional names: - Zollinger-Ellison syndrome
General
Zollinger-Ellison syndrome is a rare condition in which gastrinomas, which are a kind of tumor, develop in the pancreas. These tumors release the hormone gastrin, causing the stomach to produce excess acid that leads to peptic ulcers. Typically, Zollinger- Ellison syndrome affects people between the age 20 to 60. Zollinger-Ellison syndrome may be caused by an inherited condition called multiple endocrine neoplasia, type 1 (MEN 1).
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Signs & symptoms
Symptoms may include abdominal pain, diarrhea, burning and aching in the upper abdomen, acid reflux, nausea, vomiting, bleeding in the digestive tract, weight loss, and decreased appetite.
Diagnosis
Diagnosis is based upon findings from medical history and physical examination. Further evaluation may include blood tests for gastrin levels, upper gastrointestinal endoscopy, ultrasound, and other imaging tests.
Treatment
Treatment includes surgical procedures to remove the gastrinomas , embolization, injecting drugs to the tumors, chemotherapy, and medication to decrease acid production ro relieve the symptoms.
Note
☝ We provide information on prescription and over-the-counter medicines, diagnosis, procedures and lab tests. This material is provided for educational purposes only and is not medical advice, diagnosis or treatment.
National Institutes of Health ∙ World Health Organization ∙ MedlinePluse ∙ Centers for Disease Control and Prevention
☝ All information has been reviewed by certified physicians from Alike
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