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Tumor lysis syndrome
Tumor lysis syndrome
by Alike Medical Team ∙ Updated on June 13, 2023
General
Tumor lysis syndrome (TLS) is a condition that may occur to people suffering from malignancy when a large number of cancer cells die in a short period and release their content into the bloodstream. These contents include high levels of uric acid, potassium and phosphorus. Due to high levels of phosphorus binding calcium in the blood, low levels of calcium are seen. People who are at greater risk for TLS are those with a large tumor burden such as leukemia, lymphoma as tumors that are highly responsive to treatment.
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Signs & symptoms
Symptoms may include nausea, vomiting, lack of appetite, fatigue, dark urine, flank pain, numbness, seizures, hallucinations, muscle cramps and spasms, and palpitations.
Diagnosis
Diagnosis is based upon findings from medical history and physical examination. Further evaluation includes blood tests.
Treatment
Treatment includes intravenous fluids, allopurinol, and rasburicase as well as correction of electrolyte imbalance.
Note
☝ We provide information on prescription and over-the-counter medicines, diagnosis, procedures and lab tests. This material is provided for educational purposes only and is not medical advice, diagnosis or treatment.
National Institutes of Health ∙ World Health Organization ∙ MedlinePluse ∙ Centers for Disease Control and Prevention
☝ All information has been reviewed by certified physicians from Alike
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