There are autoimmune diseases that are serum negative and do not show up in blood tests. There are other tests available to look for these. For example, I recently had a lip biopsy to test for Sjögren’s syndrome.

✋hi space Junkie. I need to look in my file for my ADVISE test results. I KNOW how frustrating it can be to feel miserable with no answers… it’s been my story too for 3 years. My test reports “strong positive ANA factor” but all subsequent tests were negative. Hang in there you are not alone. I’m always here if you need to vent.

I’m also going through the same issues. I have fibromyalgia and other medical issues but the chronic pain in my joints has gotten worse over the last four years it’s pretty much I’m in pain constantly every day now I was also tested for multiple things and had a positive ANA and told that I probably have lupus but when I went for the lupus testing now it’s inconclusive so now they don’t really know

I can relate with so much of what a lot of you are saying. I have fibromyalgia, and at least one form of arthritis (OA & RA), I too have had very large and painful swollen lymph nodes in my head and neck with severe facial/neck pain. I also have TMJ so I don't know how much if at all that's a factor. My blood counts have also been off that started before I found the lymph nodes last September, but have progressively gotten worse in the last 9 months. If you get any answers Spacejunkie I'd love to hear from you.