My doctor doesnt like any injections, as it's and all or nothing trial that you cant stop once it has entered your system. I had really bad response to Lupron. I had chemo 5 monthscearlier and a great side effect was huge reduction in migraines. Oncologist sold Lupron as possibly stopping my migraines completely. It was only supposed to be a single month dosage. But it totally backfired. It brought back daily migraines and stronger, meaner than before chemo. It was over 3 months before a single day without a migraine. I hear good responses. But hate the commercial where they misleading choose to advertise that 95%+- of current botox user wish they had asked their doctors sooner. No kidding. If it was terrible, they wouldnt be current botox users!!! Sorry i cant answer, but this is why i chose not to try it.