I’ve been on many anxiety/depression meds. Only one did not work. In fact, it did make my depression worse. My Psychiatrist would listen to me when I told him what was going on. He kept increasing the dose and tell me to come back in 2 weeks. The reason I’ve been on many different meds is because I started taking them in the early 80’s. I’ve been of them for about 10 years. I just recently started again on meds again. I started on one that I remember works well for me. Most of the meds used for depression can work for someone for a while then stop working all together. Personally, I wouldn’t be afraid to try a new med.