Hey! I’ve been on rituxan for about 8ish months now. I have a port placed in my chest so my hands were accessible, but it just depends where they place your IV if you don’t have a port. I got super tired for like, 1.5-2 weeks after, but no pain. Just some extra caffeine in the mornings and going to bed early helped a lot to help me get through. Also, drinking a lot more extra water for the next few weeks helps your body process and filter the medicine, making you feel better! If you have any more questions feel free to shoot me a message