When will I feel better? I have been on 25 mcg Synthroid since 2018. My Hashimoto’s was probably going on long before that; it took 3 doctors to finally check my T4. I recently had a physical and my levels have dropped again. I was chalking the symptoms up to new job stress. I started 50mcg four days ago, and the joint pain is vanishing but the fatigue and brain fog remain the same. Any thoughts on when I’ll see a real difference, or do I need a higher dose?