Should I take lamictal in the morning or at night? I started at 25mg and am now on 50mg working my way up to at least 100mg to treat bipolar II. I’ve noticed lately that I feel tired/ run down almost all day. By like 10-11am I’m already ready to leave work and can’t get motivated to do complicated tasks. I also feel like my head is sort of empty(?). My sleep hasn’t changed so my thought is it has to be the medication.