Well, I found out what happens when I take my Pristiq 6 hrs late. I realized yesterday afternoon that I hadn't taken it yet, but I thought as long as I took it then, I would be fine. There was a day a couple weeks ago when I for got it entirely and didn't even know it until the next day when it as time for the next dose and I noticed it was still in my sorter. This time, no such luck. I got SUPER moody and irritable and had an argument with my husband because of it. By this afternoon (I took it on time this morning), my moods were stable again, but the physical ramifications of the imbalance kicked in. I'm achy, hot and cold, and fatigued to the bone after a busy day. Ugh. I haven't said anything to my husband, because I don't want to seem like I'm dismissing the points he made during our discussion (like I'm saying, "Oh well, I just f-ed up my meds, so what if I was a b**** to you?") and I don't want him dismissing the points I made for the same reason. But I also don't want him worrying that this is going to be a regular occurrence, given my brand new diagnosis. We're both still learning how to navigate this, and I don't want to plant more worries in his head than are already there.