It sounds like the dose is too much. I had the same problem with 290 mg but asked to be put on 145 mg. Eating a plant based diet along with a daily stool softener has helped. Talk with your doctor about reducing the dose. I even had opened the higher dose and stirred it into a glass of water and drank the half I needed. On average for me, it takes about four hours to get relief. I wish you the best. 🤗

What dose did they start you on? Because you should try 76mg then 145mg and see how you do.

I started on 76 I believe and it gave me a lot of diarrhea but tbh I would take diarrhea over the debilitating constipation I was experiencing.

I had this issue on Linzess as well. I was on it for several months though because it was still better than the constant constipation. I will say it took my body a while to level out on Linzess, and for a while I was neither constipated nor having diarrhea. Unfortunately that didn't last for me so I asked my doctor about switching meds (after we tried different doses). I'm on Lubiprostone now and I'm in way less pain. I'm still constipated but I'm way less bloated and I have more energy and I can sleep better. I've only been on it for a couple weeks now though.

I think that is also called, Amitiza. I tried it and liked the results. They are more gentle than Linzess. My insurance wouldn’t cover it because it was a new medication and no generic medication was available. I am going to see if my insurance covers Lubiprostone. Thank you for posting! 💕

Take it less often also besides smaller doses. Skipping days