140 mcg does . I’m on the toilet so much . Try to stay near a toilet 😩

I don’t remember the dose I was on but linzess blew everything out😅 definitely stay close to a toilet while you adjust

Lord have merthyyy 😥 😥

Geez reading the comments makes me feel like mutant. Im on 290 mg and still have to take a laxative of some kind (stimulant or non) every single day to go to the bathroom at all 😬

Very much so! That was the dose I started with. I cut it back to 145 mg. It’s much easier on my digestive tract with positive results.

I took my Linzess at night and thought it worked well. I realized that it caused me to have gas and it would wake me up. True story. 🫣 LOL!

Yep. I wouldn’t start at 290. Start low & go up as needed. The more liquids you drink the more diarrhea & water poops you will have. It will cause straight up water to come out of your colon, so don’t take it unless you can be home & able to go to the toilet multiple times. I don’t recommend drinking more than 16 Oz of water before or after you’ve taken it. Just enough water to get things moving.

Hi. I'm Bruce. I take Linzess, 290 every day. I'm STILL constantly constipated. I haven't pooped in 9 days. It's time to get cleaned out. Early this morning I started with 45mls of MOM. This was at 420 am. Then I went to bed hoping it would produce a BM. I woke up still constipated at 630am. I continued waiting, hoping it would work. Then at 145pm I took 30mls of lactulose. STILL NO BM. Then at 515pm I took a magnesium citrate tablet. NOW, at 700pm I still havent had a BM and now I'll take 45mls more of Milk of magnesia and hope and pray that I will finally GO. I suffer this because I have to take high doses of narcotics for my hip pain. What a life. I'm 70. I'll continue this story as it progresses. I'm 9 days constipated so far. I've curtailed my food intake to 1 meal a day.