I don't really have a solution to this, but you're not alone. Medisafe will remind me repeatedly but I often just don't take it. For me, I feel like it's a matter of a subconscious feeling like I don't deserve to feel better, so I've been trying to tackle that. Sorry you're going through this, too.

I had to get a little dedicated alarm clock to put right next to my pills, so you have to go over to your pills to turn off the alarm. I keep them in the kitchen so the water is right there too. And also use a pill organizer or a timer lid so you know for sure if you've taken it that day. Soon it'll become habit.