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Dollette

Updated 1y ago

Why Does Missing a Day of Depression Medication Make Me Feel Amazing?

I’m a little confused. I take sertraline for depression daily but I always feel kind of meh and just emotionless, if I miss a day on my meds I feel amazing, but I have to take it again the next day or I feel extremely down. Eg. Take one Monday, miss Tuesday, take one Wednesday. Does anyone have any idea why this happens? I’ve tried to look it up but I can’t find anything on it.

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LunarMoth

1y

It almost sounds a bit like the response people have to antidepressants if they have undiagnosed Bipolar Disorder. Antidepressants can trigger manic episodes, and would likely also be followed by a subsequent depressive episode
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LunarMoth

1y

Just might be worth bringing up this reaction to the medication with whoever prescribed it to you? It's possible it's not the right class of medications for you, but you would have to consult a medical professional
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Dollette

1y

this does sound very possible. Thanks for the feedback!
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SuicideShrimp

1y

I’m not super qualified but what I’ve learned as a neuroscience minor is that setraline or Zoloft is an SSRI selective serotonin reuptake inhibitor serotonin is being pushed into your system at the same time your body that also naturally makes serotonin does something called reuptake or the reabsorption of serotonin into the neurons. The SSRI actually stops this from happening so that more serotonin is available to pass between nearby nerve cells and not just absorbed. When you stop taking it your body is trying to compensate for the missed dose but this means the next day your body is low on serotonin it has gotten used to your med increasing the intake of serotonin so you will feel mood switches if you start on and off. Also starting and stopping is not only bad for mental health but for physical health as well I’m not entirely versed on the effects on the physical body but withdrawal is a sucky symptom to have. I recommend talking to your psych about SSRIs and maybe trying an antidepressant that is not an SSRI if it makes you feel numb or emotionless
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Dollette

1y

thanks for letting me know, I’ll be sure to ask my doctor if he knows why this happens.
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The.Morrigan

1y

I have the same thing, either I have 0 emotions or a 100 no in-between. I'd definitely bring it up with your doctor to make sure everything is ok <3
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Bookworm23

1y

This is exactly what happened to me. I have tried so many different antidepressants, and Lexapro/Sertraline had the worst side effects (emotionless, no sex drive, didn't care about anyone or anything, suicidal thoughts). I agree with what everyone is saying here - talk to your provider and see if they can get you on something else. I wish someone would have told me years ago that being "emotionless" wasn't normal. I felt my best when I went off these meds. I'm currently on fluoxetine and Buspirone. I highly recommend taking the Genesight test to see what medication works/doesn't work for you.
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Dollette

1y

thanks! I’ll give it a try

The content in this post is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

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